The Methods section describes how you studied the problem.
It is important to be detailed – a knowledgeable reader should be able to reproduce the experiment.
Any previously published procedures should not be re-written in detail. Those can be noted in the References or described in the Supporting Materials sections.
The equipment and materials used in experiments should be identified, along with their sources if there is the chance for variability of quality of these items. If the work is computational or theoretical, code, computational, or analytical methods should be described.
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